HYPOGONADISM

Hypergonadotropic hypogonadism

• Hormone resistance (androgen, LH insensitivity).

• Gonadal defects (e.g., Klinefelter's syndrome, myotonic dystrophy).

• Drug induced (e.g., spironolactone, cytotoxins).

• Alcoholism, radiation-induced.

• Mumps orchitis.

• Anatomic defects, castration.

 

Hypogonadotropic hypogonadism

• Pituitary lesions (neoplasms, granulomas, infarction, hemochromatosis, vasculitis)

• Drug-induced (e.g., glucocorticoids). Hyperprolactinemia.

• Genetic disorders (Laurence-Moon-Biedl syndrome, Prader-Willi).

• Delayed puberty.

• Other:  chronic  disease,  nutritional deficiency,  Kallmann's syndrome, idiopathic isolated LH or FSH deficiency.